Proteomics and Cell Signalling

Most cells in the human body are subject to continuous change. Old or dysfunctional cells are replaced on a regular basis. In addition, each cell is constantly sensing its environment, and can adapt in response to specific cues, if necessary. This is essential to ascertain proper physiological function. All signal transduction processes consist of individual protein-protein interactions, which are assembled into pathways and networks. They are regulated by protein abundance and localization, and modulated by post-translational modifications. Any drug intervention, therefore must alter at least of these features in order for it to be effective.